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Alteplase (t-PA) Nursing Pharmacology Considerations

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What is the Generic Name for t-PA?

alteplase

What is the Trade Name for alteplase?

t-PA

What are the Indications of Alteplase (t-PA) Nursing Pharmacology Considerations?

MI, acute ischemic stroke, occluded central lines

What are the Actions of Alteplase (t-PA) Nursing Pharmacology Considerations?

converts plasminogen to plasmin which degrades the fibrin found in clots

What is the Therapeutic Class of Alteplase (t-PA) Nursing Pharmacology Considerations?

thrombolytics

What is the Pharmacologic Class of Alteplase (t-PA) Nursing Pharmacology Considerations?

plasminogen activators

What are the Nursing Considerations of Alteplase (t-PA) Nursing Pharmacology Considerations?

  • contraindicated in active bleeding
  • monitor closely for signs of bleeding (petechiae)
    • q 15 min X1hr
    • q 15-30 min X 8 hr
  • use caution with patient who have had recent surgery
  • may cause intracranial hemorrhage
  • monitor for anaphylaxis
  • use caution with uncontrolled hypertension
  • assess neuro status during therapy

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