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02.13 Mycotoxins and Mycotoxicosis

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Overview

  1. Mycotoxins are secondary metabolites made by small fungi associated with disease and death in living organisms thus causing mycotoxicosis (the effect of exposure or ingestion to mycotoxins).

    1. How produced- Natural metabolites produced by fungi that affect living organisms. Found in our food chain.
      1. Mycotoxins that kill bacteria are called antibiotics
      2. Mycotoxins that are toxic to plants are called phytotoxins
      3. Mycotoxins that affect humans are called mycotoxins
        1. Health effects to humans
          1. Aflatoxins known to affect liver and cause cancer. Used in bioterrorism.
          2. Citrinin- Nephrotoxin in humans
          3. Ergot alkaloids- Causes Erogotism (St. Anthony’s Fire) That effects CNS and gangrene by affecting blood flow to extremities.
          4. Fumonisins- Associated with esophageal cancer in humans.
          5. Ochratoxin- Attacks kidneys
          6. Molds that Impact indoor Air Quality are Alternaria, AspergillusCladosporium, and Penicillium
  2. What is meant by Mycotoxicosis

    1. Illness to humans and animals caused by either
      1. consumption of fungal contaminated foods
      2. skin contact with mold-infested substrates
      3. inhalation of toxins secreted by fungal spores
    2. Fungi that produce toxins often in conditions of warmth, moisture and humidity, therfore more common in tropical zones.
    3. Treated mycotoxicosis through:
      1. Immunotherapy
      2. Low Mold Diet
      3. Vaccines Created from Cultures
      4. Antifungal Medications
      5. Prescribe Specific Nutrients Needed for Detox
      6. Cleaning/Remediation of Environment

Reference Links

Video Transcript

Today we’re going to be talking about mycotoxins and mycotoxicosis.

In this lesson on mycotoxins and mycotoxicosis we will cover  what mycotoxins are and give examples. We will discuss different mycotoxins that affect human health specifically. And then we will describe what mycotoxicosis and how it is treated.

Mycotoxins are secondary metabolites made by small fungi associated with disease and death in living organisms. This is a photo taken in New Orleans after Hurrican Katrina: depicting Mold infestations in bedroom of home in a new Orleans neighborhood. This particular house did not flood and had only minor exterior damage, but small leaks during the storm plus being vacant for weeks resulted in homeowners returning to this mold infestation which is deemed unsafe because of this black mold produces mycotoxins.

 

Mycotoxins are natural secondary metabolites produced by fungi and that specifically have an affect on other living organisms. They are found in our food chain from our crops to meat, cheeses, spices, fruits and even in our beverages. Mycotoxins that are toxic to bacteria have become a source of our antibiotics (penicillin is a mycotoxin).  Mycotoxins that are toxic to plants are called phytotoxins.

 

There are several mycotoxins that affect human health in different ways. Aflatoxins are poisonous known to affect liver and cause cancer. Used in bioterrorism. Citrinin- Nephrotoxin in humans. Ergot alkaloids- Causes Erogotism (St. Anthony’s Fire). This affects CNS and Gangrene by affecting blood flow to extremities. Fumonisins- Associated with esophageal cancer in humans. Molds that Impact indoor Air Quality are Alternaria, Aspergillus, Cladosporium, and Penicillium.

Mycotoxicosis is defined as  the Illness to humans and animals caused by either consumption, skin contact or inhalation. Toxins often in conditions of warmth, moisture and humidity.  More common in tropical areas.


Ways to treat mycotoxicosis include immunotherapy (administering antibodies, Consuming a low mold diet (no cheese, beer, etc). Vaccines created from fungal cultures. Prescribing antifungal medications, prescribing specific nutrients needed for detox and lastly decontaminating/remediation of the environment.

 

So to review, mycotoxins are secondary metabolites made by fungi that affect living organisms. Antibiotics are simply mycotoxins that are toxic to bacteria. Human health is affected by a variety of mycotoxins that affect different organs. and mycotoxicosis is an illness to animals and humans caused by mycotoxins.

 

We love you guys! Go out and be your best self today! And as always, Happy Nursing!

 

 

 

 

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