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12.25 Ampicillin (Omnipen)

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Generic Name

Ampicillin

Trade Name

Principen

Indication

Skin infections, soft tissue infections, otitis media, sinusitis, respiratory infections, GU infections, meningitis, septicemia

Action

Bactericidal, broader spectrum than penicillin, binds to cell wall leading to bacterial cell death

Therapeutic Class

Anti-infective

Pharmacologic Class

Aminopenicillin

Nursing Considerations

• Contraindicated in penicillin allergy, use caution in renal insufficiency
• May lead to seizures, diarrhea, anaphylaxis, superinfection
• Assess for infection
• Monitor liver function tests
• Instruct patient on signs of superinfection: furry overgrowth on tongue,
vaginal itching, loose and foul smelling stool
• Pt should not use with oral contraceptive use.

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