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13.02 Chlorpromazine (Thorazine)

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Generic Name

Chlorpromazine

Trade Name

Thorazine

Indication

Second line treatment of schizophrenia and psychosis, nausea/vomiting, pre-op
sedation, acute intermittent porphyria, headache, bipolar

Action

Exhibits anticholinergic activity, alters effects of dopamine in CNS

Therapeutic Class

Antipsychotic, antiemetic

Pharmacologic Class

Phenothiazines (dopamine D2 receptor antagonist)

Nursing Considerations

• May cause neuroleptic malignant syndrome, sedation, tardive dyskinesia,
hypotension, agranulocytosis
• Assess mental status prior to and during treatment
• Monitor blood pressure
• Ensure patient is taking medication
• Monitor CBC and liver function tests
• Instruct patient not to skip doses or double dose.

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