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14.12 Diphenoxylate-Atropine (Lomotil)

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Generic Name

Diphenoxylate/atropine

Trade Name

Lomotil

Indication

Treatment for diarrhea

Action

Inhibits GI motility via anticholinergic effects

Therapeutic Class

Antidiarrheal

Pharmacologic Class

Anticholinergic

Nursing Considerations

• Contraindicated with angle-closure glaucoma, dehydration
• Structurally related to opioids so use caution with patients that have aller-
gies to opioids
• May cause constipation, tachycardia, dizziness, ileus
• Monitor liver function as medication is excreted by the liver
• Ensure that client is taking medication as prescribed and not double dosing

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