26.03 Cortisone (Cortone)

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Generic Name


Trade Name



Management of adrenocortical insufficiency (Addison’s Disease). Replace cortisol
in states of deficiency, suppress inflammation and normal immune response.


The adrenal glands sit on top of the kidneys.
The adrenal glands excrete steroid hormones, including cortisol that play a role in
increasing blood sugars, immune suppression, and metabolism of fat, protein, and
carbohydrates, as well as decreasing bone formation.

Therapeutic Class

Antiasthmatics, corticosteroids

Pharmacologic Class


Nursing Considerations

• Excreted by the liver – monitor liver profile
• Avoid in active untreated infections
• May cause CNS alterations
• May cause peptic ulcers
• May cause Cushingoid appearance (buffalo hump, moon face)
• Weight gain
• Osteoporosis
• Decrease wound healing
• May elevate blood sugars
• May increase cholesterol and lipid values