Metronidazole (Flagyl) Nursing Considerations

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Generic Name


Trade Name



intra-abdominal infections, gynecoligical infections, skin infections, bone and joint infections, CNS
infections, septicemia, endocarditis, amebic liver abscess, peptic ulcer disease


Inhibits DNA and protein synthesis in bacteria, bactericidal

Therapeutic Class

anti-infectives, antiprotozoals, antiulcer agents

Pharmacologic Class


Nursing Considerations

• do not take with alcohol-disulfiram reaction
• assess for infection before and during treatment
• obtain cultures before therapy
• monitor neurologic status: parasthesia, weakness, ataxia, or seizures
• monitor intake and output, daily weights
• may alter liver enzyme tests

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Okay, let’s take a look at the drug metronidazole. Also known as fragile. This is an oral medication, but it also comes in other forms like Topol, as you can see here, vaginal rectal and IV forms, the therapeutic class, or how metronidazole works in the body is an anti-infective and anti proteol. And also an anti ulcer agent, the pharmacologic class, or the chemical effect of this drug is a nitro imidazole metronidazole works as a bacterial Cytal agent inhibiting DNA and protein synthesis in bacteria. We use this drug for intraabdominal infections for gynecologic infections, skin infections, bone and joint infections, central nervous system infections septicemia also for endocarditis am EIC liver disease and peptic ulcer disease. 

So remember metronidazole is Ayal agent. So sometimes good bacteria is destroyed with the bad bacteria, which can create some side effects, including abdominal cramps diarrhea. Also, we can see things like anorexia and dry mouth. So some of the nursing considerations assess for infection in your patient before an during treatment with fragile obtain cultures prior to the start of therapy, monitory your patients, eyes and OS daily weights, as well as their logic status, including weakness paresthesia and seizures. Make sure to teach your patient to not take with alcohol as this can result in a diol reaction. So guys, one more thing with this drug is it is not uncommon for patients to get the, is metallic taste in their mouth, which is kind of weird. Um, but just recognize that and make them aware of that before it happens and also fragile or meite is always only active against anaerobic bacteria and has little to no effect against aerobic bacteria, which means it’s really important that this drug is prescribed for the correct infection. That’s it for metronidazole or fragile now go out and be your best self today and as always happy nursing the.

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