Ondansetron (Zofran) Nursing Considerations

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Generic Name


Trade Name





blocks effects of serotonin on vagal nerve and CNS

Therapeutic Class


Pharmacologic Class

5-HT3 antagonist

Nursing Considerations

• administer slowly over 2-5 minutes – fatal QT prolongation and VTach, respiratory arrest
• may cause headache, constipation, diarrhea, dry mouth
• asses nausea and vomiting
• assess for extrapyramidal symptoms
• monitor liver function tests

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Hey guys, let’s talk about Onan Tron also known as Zo Fran. This is an injectable medication, as you can see here, the therapeutic class of ondansetron or how it works in the body is an anti medic, the pharmacologic class, or the chemical effect of on Dan Tron is a five HT, three antagonist. So on Dan Tron blocks the effects of serotonin on the VA nerve and the central nervous system, which is why we use this drug for the treatment of nausea and prevention. And also for vomiting. Some of the side effects that on Antron can cause are things like headache, constipation, dry mouth, and diarrhea. 

So in rare cases on Antron can cause extra pyramidal symptoms. So be sure to assess your patient for these. And also you want to assess your patient’s nausea and vomiting to be sure they’re only receiving the amount necessary. Also monitor your patient’s liver function tests. And it’s important to administer on Tron slowly over two to five minutes because rapid administration guys can cause fatal QT, prolongation, VTAC, and respiratory arrest, and it’s important teacher patient to report symptoms to the provider. So the maximum recommended daily doses vary depending on why your patient is receiving on Deru. So for instance, chemo patients tend to receive a higher dose than post-surgery patients do. So just be aware of this, depending on which area you are working in, that’s it for or on Tron orzo Fran. Now go out and be your best self today and as always happy nursing.

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