Pancrelipase (Pancreaze) Nursing Considerations

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Generic Name


Trade Name



pancreatic insufficiency, ductal obstruction


replacement of pancreatic enzymes: lipase, amylase, protease

Therapeutic Class

digestive agent

Pharmacologic Class

pancreatic enzyme

Nursing Considerations

• contraindicated with pig products allergy
• can cause shortness of breath, nausea, diarrhea, rash
• assess nutritional status
• monitor for steatorrhea
• may increase uric acid levels
• instruct patient to follow diet
• take with meals and snacks

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Okay, let’s take a look at pancrea lipase, also known as pancreas or Creon. This is an oral medication. As you can see here with this packaging for Creon, the therapeutic of pancrea lipase or how it works in the body is a digestive agent. And the pharmacologic class is a pancreatic enzyme. So pancrea lipase works by replacement of pancreatic enzymes, including lipase, amylase, and protease. We use this drug for pancreatic insufficiency, as well as ductal obstruction with pancrea lipase. We can see a few side effects, including shortness of breath, nausea, diarrhea, and rash, a few nursing considerations for pancrea lipase. It is contraindicated. If the patient has any allergies to pig products, be sure to monitor your patient. Foria pancrea lipase may increase your acid levels. So be aware if your patient has gout or is prone to out, teach the patient that they should follow their given diet, as well as take their medication with meals and snacks, and be sure you assess your patient’s nutritional status. Guys. It’s important to know that if a meal is skipped, then the pancrea lipase dose can also be skipped. This might be a question that a patient has. And also here is an off labelable use. We often use this medication to unclog blocked feeding tubes. So this involves crushing a tablet of pancrea lipase. And guys, when I worked in the ICU, this is definitely something I did often, and it really does work. 

That’s it for pancrea lipase or pancreas or Creon now go out and be your best self today. And as always happy nursing.

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