Paroxetine (Paxil) Nursing Considerations

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Generic Name


Trade Name



major depressive disorder, OCD, anxiety, PTSD


block reuptake of serotonin in CNS

Therapeutic Class

antianxiety agent, antidepressant

Pharmacologic Class


Nursing Considerations

• do not use with MAOIs
• can cause neurolyptic malignant syndrome, suicidal thoughts, serotonin syndrome, constipation,
diarrhea, insomnia
• decrease effectiveness of digoxin
• increase bleeding with warfarin
• assess for suicidal thoughts

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Hey guys, let’s talk about paroxetine also known as Paxil. This is an oral medication, as you can see here, The therapeutic class of Proxin is an anti-anxiety agent, as well as an anti antidepressant. Remember, this is how the drug works in the body and it’s pharmacologic class or the chemical effect of the drug is an SSRI, which is a serotonin selective reuptake inhibitor Perine works because it blocks the re uptake of serotonin. And in the central nervous system, we use Perine for major depressive disorder for obsessive compulsive disorder, for anxiety, and also for post traumatic stress disorder. 

So some of the side effects that we see with Paxil Oroxine and antidepressants in general are suicidal thoughts, constipation, diarrhea, and insomnia, a few nursing considerations for Perine do not use if the patient is also on mais, there are some drug interactions with Perine, including it increases bleeding. If the patient is on warfarin, it also decreases the effect of dein Proin may cause neuroleptic malignant syndrome, as well as serotonin syndrome. Be sure that you assess any suicidal thoughts in your patient and make sure that they know to report suicidal thoughts to the provider. So guys with antidepressants, they are known for not working right away. So be sure to teach your patient that it may take a few weeks to see any results of the drug. And also guys in patients who have a liver disease, they need to be started on a lower dose because Perine is dependent on the liver. That’s it for paroxetine or Paxil now go out and be your best self today. And as always happy nursing.

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