Promethazine (Phenergan) Nursing Considerations

Join to watch the full lesson now.

Included In This Lesson

Study Tools


Generic Name


Trade Name



allergic reactions, nausea and vomiting, sedation


Blocks the effects of histamine, histamine plays a role in the immune response.  Plays an inhibitory role on the chemoreceptor trigger zone in the medulla leading to an antiemetic effect.  Possess anticholinergic properties producing CNS depression.

Therapeutic Class

antiemetic, antihistamine, sedative/hypnotic

Pharmacologic Class


Nursing Considerations

• IV administration may cause damage to tissue, hypertension, impaired liver function
• monitor for neuroleptic malignant syndrome, confusion, sedation
• may cause CNS depression
• assess sedation level and anticholinergic effects

Join to watch the full lesson now.


Hey guys, let's talk about the drug promethazine also known as Phenergan. This is an oral medication, as
you can see here, but it also comes in the injectable form. So the therapeutic class of pro methazine is
an antiemetic an antihistamine, and also a sedative hypnotic. Remember the therapeutic class is how
the drug works in the body. The pharmacologic class of promethazine or the chemical effect is a phenyl
thiazide. So promethazine blocks the effects of histamine. And remember histamine plays a role in the
immune response. So promethazine plays an inhibitory role on the chemo receptor trigger zone in the
me doula, which leads to an antiemetic effect. Also promethazine possesses, anticholinergic properties,
Perue CNS depression. We use promethazine for allergic reactions, nausea, and vomiting, and also for
sedation. So some of the side effects that we see with promethazine are confusion, sedation, CNS,
depression, and hypertension.
Let's take a look at a few nursing considerations for promethazine IV administration may cause damage
to tissue. So be aware of this IV administration can also cause hypertension and impaired liver function.
Be sure to assess your patient's sedation level as well as any anticholinergic effects and monitor for
neuroleptic malignant syndrome, teach your patient to report any signs of an allergic reaction to their
provider. So there have been reports of respiratory depression and death in children under two years
old who receive promethazine. So if possible, pro Meye should be avoided altogether in, um, children
under the age of two. But if this isn't possible, the absolute lowest dose should be given in this pediatric
population. That's it for promethazine or Phenergan now go out and be your best. So off today and as
always happy nursing for.

Join to watch the full lesson now.