Vasopressin (Pitressin) Nursing Considerations

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Generic Name


Trade Name



management of diabetes insipidus, VT/VF unresponsive to initial shock, GI hemorrhage


increases water permeability of the kidney’s collecting duct and distal convoluted tubule leading to water retention, also increases peripheral vascular resistance leading to increased BP

Therapeutic Class


Pharmacologic Class

antidiuretic hormone

Nursing Considerations

• use caution with HF and CV disease
• contraindicated in renal failure and hypersensitivity to pork
• monitor BP, HR, and EKG during therapy
• monitor urine specific gravity and osmolality
• weigh patient and assess for edema
• monitor electrolyte panel
• do not use with alcohol

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Okay, let’s take a look at the drug vasopressin. Also known as Trein. This is an injectable medication. As you can see here, the therapeutic class of vasopressin or how it works in the body is a hormone. The Cologic class of vasopressin is an antidiuretic hormone. And remember, this is its chemical effect. So vasopressin works by increasing water permeability of the kidneys, collecting duct and distal tubal. This leads to water retention increases PBR and leads to an increased blood pressure. We use vasopressin for diabetes, inci, VTAC, and VFI, which is unresponsive to initial shock. And also also for GI hemorrhage. Some of the side effects that we can see with vasopressin are edema, AFib, bradycardia, and abdominal cramping. A few nursing considerations for vasopressin use caution in patients who have heart failure or cardiovascular disease in general, vasopressin is Contra in patients with renal failure or a hypersensitivity to pork monitor your patient’s blood pressure, heart rate, EKG, electrolyte panel, their weight and their urine specificity and gravity assess for edema in your patient and teach your patient to not use vasopressin with alcohol guys. It’s definitely important to know that elderly patients have an increased response to vasopressin with water homeostasis, and if extra occurs it can lead to necrosis. So is if there is absolutely any sign at all of ex extra, the IV should be stopped immediately in a new site started that’s it for vasopressin or Petin now go out and be your best self today. And as always happy nursing.

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