09.09 Insulin – Long Acting (Lantus)

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Generic Name

detemir, glargine

Trade Name

Levemir, Lantus


hyperglycemia with diabetes type 1 and 2, diabetic ketoacidosis


stimulates uptake of glucose into muscle and fat cells, inhibits production of glucose in the liver,
prevents breakdown of fat and protein

Route Onset Peak Duration
Detemir 3-4 hr 3-14 hr 24 hr
Glargine 3-4 hr none 24 hr


Therapeutic Class

antidiabetics, hormones

Pharmacologic Class


Nursing Considerations

• assess for symptoms of hypoglycemia or hyperglycemia
• monitor body weight over time
• may cause decreased inorganic phosphates, potassium, and magnesium
• monitor blood sugars every 6 hours, monitor A1C every 3-6 months