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09.08 Insulin – Mixtures (70/30)

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Generic Name

Lispro mixture, Aspart mixture, NPH/regular

Trade Name

Humalog Mix, NovoLog Mix, Humulin 70/30, Novolin 70/30

Indication

hyperglycemia with diabetes type 1 and 2, diabetic ketoacidosis

Action

stimulates uptake of glucose into muscle and fat cells, inhibits production of glucose in the liver,
prevents breakdown of fat and protein

Route Onset Peak Duration
Lispro mix 15-30 min 2-3 hr 24 hr
Aspart mix 15 min 1-4 hr 18-24 hr
NPH regular 30 min 4-8 hr 24 hr

 

Therapeutic Class

antidiabetics, hormones

Pharmacologic Class

pancreatics

Nursing Considerations

• assess for symptoms of hypoglycemia or hyperglycemia
• monitor body weight over time
• may cause decreased inorganic phosphates, potassium, and magnesium
• monitor blood sugars every 6 hours, monitor A1C every 3-6 months

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