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This is when we want to be negative. Collection for this is through a serum separator tube or a gold top. When lab values are increased, meaning they're greater than 20 units per mL, this is the preclinical phase of the disease. This is going to tell us that this is a high likelihood that the patient will develop rheumatoid arthritis. Look at all that inflammation in the joint. If it's decreased or below 19 units per mL, that means, or is evaluated in patients and seen as effective treatment for rheumatoid. Some linchpins for this lesson are that the cyclic citrullinated peptide ia a lab value that detects the antibodies that were formed in response to the peptide being present in the body. A normal value is below 19 units per mL and considered negative. An increased value would be greater than 20 units per mL, and shows a strong likelihood that rheumatoid arthritis is the diagnosis. But remember this lab doesn't stand alone in evaluation. We have to have a positive rheumatoid factor in addition to it, in order to actually lead to our diagnosis of rheumatoid arthritis. Now, what we want to see are decreased values, decreased values, show us evidence that treatment has been effective. Everybody did great this lesson. You can do this. This wraps up our lesson on CCP. Now go out and be your best self today. And as always happy nursing.
References:
- https://www.uptodate.com/contents/biologic-markers-in-the-diagnosis-and-assessment-of-rheumatoid-arthritis?sectionName=Anti-citrullinated%20peptide%20antibodies&search=cyclic%20citrullinated%20peptide&topicRef=7504&anchor=H4&source=see_link#H5
- https://pubmed.ncbi.nlm.nih.gov/26199263/
- https://ltd.aruplab.com/Tests/Pub/0055256
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