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13.06 Olanzapine (Zyprexa)

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Generic Name

olanzapine

Trade Name

Zyprexa

Indication

schizophrenia, mania, depression, anorexia nervosa, nausea/vomiting related to chemotherapy

Action

antagonizes dopamine and serotonin

Therapeutic Class

antipsychotic, mood stabilizers

Pharmacologic Class

thienobenzodiazepines

Nursing Considerations

• do not use while breastfeeding
• can cause neurolyptic malignant syndrome, seizures, suicidal thoughts, insomnia, tardive
dyskinesia, agranulocytosis, constipation, tremors
• assess mental status
• monitor hemodynamics
• assess blood sugars
• assess intake and output
• monitor liver function tests

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