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08.08 Paroxetine (Paxil)

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Generic Name

paroxetine

Trade Name

Paxil

Indication

major depressive disorder, OCD, anxiety, PTSD

Action

block reuptake of serotonin in CNS

Therapeutic Class

antianxiety agent, antidepressant

Pharmacologic Class

SSRI

Nursing Considerations

• do not use with MAOIs
• can cause neurolyptic malignant syndrome, suicidal thoughts, serotonin syndrome, constipation,
diarrhea, insomnia
• decrease effectiveness of digoxin
• increase bleeding with warfarin
• assess for suicidal thoughts

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