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18.06 Propylthiouracil (PTU)

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Generic Name

propylthiouracil

Trade Name

PTU

Indication

hyperthyroidism

Action

inhibits thyroid hormones

Therapeutic Class

Antithyroid Agent

Pharmacologic Class

none

Nursing Considerations

• hepatotoxicity, nausea, vomiting, agranulocytosis
• monitor symptoms of hyperthyroidism
• monitor for hypothyroidism
• monitor WBC and liver function tests
• weight patient frequently
• may cause leukopenia, thrombocytopenia, jaundice
• take with meals

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