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13.05 Quetiapine (Seroquel)

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Generic Name

quetiapine

Trade Name

Seroquel

Indication

schizophrenia, depressive disorder, mania

Action

dopamine and serotonin antagonist

Therapeutic Class

antipsychotic, mood stabilizers

Pharmacologic Class

none

Nursing Considerations

• may cause neurolyptic malignant syndrome, seizures, dizziness, palpitations, weight gain,
anorexia
• QT interval prolongation
• don’t use with CNS depressants
• assess weight frequently
• monitor liver function test and CBC
• may increase cholesterol

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