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06.10 Streptokinase (Streptase)

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Generic Name

streptokinase

Trade Name

Streptase

Indication

pulmonary embolism, DVT, occluded lines, arterial thrombus

Action

converts plasminogen to plasmin which degrades fibrin clots

Therapeutic Class

Thrombolytic

Pharmacologic Class

plasminogen activators

Nursing Considerations

• contraindicated with active bleeding, hypersensitivity, bronchospasm, intracranial hemorrhage,
hypotension
• begin therapy as soon as possible
• monitor vital signs continuously
• monitor closely for bleeding
• monitor hemodynamics
• avoid invasive procedures

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