A. Derivative of the natural plant anticoagulant known as coumarin
B. Most commonly prescribed oral (PO)
C. Requires careful monitoring
1. Prothrombin time/international normalized ratio (PT/INR)
1. 2.0-3.0 while taking blood thinners
1. 11-13.5 seconds
II. Mechanism of Action
A. Inhibits vitamin K–dependent clotting factors II, VII, IX, and X
A. Atrial fibrillation
B. DVT / PE thrombo-prevention
C. DVT / PE treatment
D. Stroke prevention
E. Prosthetic heart valve
F. Post-MI prevention / treatment
G. Unstable angina
A. Recent trauma
B. Active internal bleeding
C. Bleeding disorders
D. Intracranial hemorrhage
E. Severe HTN
F. Bacterial endocarditis
G. Liver failure
H. Kidney failure
4. Mustard greens
6. Brussel sprouts
1. Green tea
VI. Side Effects
2. Red or brown urine
3. Black or bloody stool
4. Severe headache or stomach pain
5. Joint pain, discomfort or swelling (after injury)
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Welcome back, today we are going to discuss coumarins – specifically coumadin.
Coumadin comes from the plant derivative, coumarin. It is the most commonly prescribed oral anticoagulant. It requires monitoring via blood work in the form of PT/INR levels.
Coumadin inhibits vitamin K dependent factors 2, 7, 9 and 10.
Coumadin indication include atrial fib, DVT/PE prevention and treatment, prosthetic heart valves, post-MI prevention and treatment, stroke prevention and unstable angina. An easy way to remember this is ADDPPSU.
Contraindications include: Bleeding disorders, bacterial endocarditis, recent trauma, active intracranial bleeding, severe HTN, intracranial hemorrhage, liver and kidney failure. Can easy way to remember these is BBRASILK.
Now, coumadin has various interactions, let’s review the medication first. Alcohol, NSAIDs, diuretics, SSRIs, vitamins, antibiotics and vaccines – which all increase coumadin effects.
Food interactions for coumadin include kale, spinach, turnip, mustard greens, broccoli, Brussel sprouts, and cabbage – all of which decrease coumadin effects.
Lastly, herbal interactions include green tea, ginkgo, feverfew, garlic, cranberry, chamomile, and ginger – all of which, increase coumadin effects.
You know now the important details regarding coumadin. Now, go out and be your best self today and as always, Happy Nursing!