CARBIDOPA AND LEVODOPA (SINEMET) Nursing Considerations

What is the generic name?

CARBIDOPA AND LEVODOPA

What is the Trade Name for CARBIDOPA AND LEVODOPA?

SINEMET

What are the Indications for CARBIDOPA AND LEVODOPA?

• INDICATIONS AND USAGE SINEMET is indicated in the treatment of Parkinson’s disease, post-encephalitic parkinsonism, and symptomatic parkinsonism that may follow carbon monoxide intoxication or manganese intoxication. Carbidopa allows patients treated for Parkinson’s disease to use much lower doses of levodopa. Some patients who responded poorly to levodopa have improved on SINEMET. This is most likely due to decreased peripheral decarboxylation of levodopa caused by administration of carbidopa rather than by a primary effect of carbidopa on the nervous system. Carbidopa has not been shown to enhance the intrinsic efficacy of levodopa. Carbidopa may also reduce nausea and vomiting and permit more rapid titration of levodopa.

References: https://open.fda.gov/